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Clinical data shows that approximately 1520% of semaglutide users experience some form of injection site reaction, though severe cases requiring treatment discontinuation remain rare

Additional mechanisms include collagen and elastin synthesis stimulation in the scalp dermis, anti-inflammatory effects that reduce the cytokine environment hostile to follicle function, and a proposed counteraction of the effects of dihydrotestosterone (DHT, the androgen primarily responsible for follicle miniaturization in androgenetic alopecia), though the DHT-related mechanism is less clearly characterized than the others

Review labels and look for third-party testing when available

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